Inflammation. Disc Degeneration. There is a relationship.
Inflammation is the body’s response to harmful
stimuli (injury, pathogens, metabolic stress – a disc herniation compressing a nerve!) as it attempts to restore itself to normal
before the harm was done. Executive Chiropractic of Iowa is always amazed at what the body can do!
Executive Chiropractic of Iowa sees its West Des Moines chiropractic care as the body’s partner in healing particularly
when spine pain is an issue. Chiropractic care utilizes
many tools like spinal manipulation, exercise, and nutrition to take care of
the body. Melatonin is one nutritional tool that is showing value
by interrupting the inflammatory process
related disc herniation that results
in back pain, neck pain and other spine related pain.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6
(IL-6) and tumor necrosis factor-α (TNF-α) are associated with intervertebral disc degeneration. (1) IL-1 β actually promotes
itself, its own expression, by upregulating NLRP3 inflammasome activation. (2)
The body controls itself down to the cellular level
via autophagy, the natural process during which the body’s
cells clean out damaged (ie, by inflammation) or unneeded parts. In
a new study, melatonin boosted autophagy
and lessened the degradation of the disc’s
extracellular matrix (technically marked by a decline
in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB
signaling pathway). The end conclusion was that melatonin prevents
intervertebral disc degeneration by promoting autophagy. (3)
Wow. Executive Chiropractic of Iowa is inspired by this research to see just
how well melatonin can work for West Des Moines back pain related
to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is a very common condition
seen at Executive Chiropractic of Iowa that positive news of
melatonin’s benefits are quite rousing. A new
study stated that melatonin could modulate
the extracellular matrix of the disc remodeling process initiated
by IL-1 β. Additionally, melatonin decreased the
inflammatory cell collection and decreased the release of associated
inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding
that melatonin interrupted the IL-1B feedback loop, researchers
postulated that melatonin may provide
the healing process of intervertebral discs after damage was
already present. (1) Executive Chiropractic of Iowa will keep
following the new research on the role inflammation plays
in West Des Moines disc degeneration and melatonin’s role in tackling
INFLAMMATION AND MELATONIN
The importance of melatonin in helping
to slow or stop painful conditions due to inflammation is rising.
The description of melatonin as a multitasking molecule affecting
mood, immunity, and energy among other things is quite fitting.
It’s also anti-oxidant, anti-aging, and anti-inflammatory, specifically
by blocking the activation of inflammasomes (4) Melatonin’s
formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine.
The pineal gland secretes melatonin naturally. Melatonin impacts
the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy
(cell-cleanout) processes. (1) Melatonin’s specific effect on
inflammation and disc degeneration is most interesting
to Executive Chiropractic of Iowa and our West Des Moines back pain patients.
CONTACT Executive Chiropractic of Iowa
Listen to this PODCAST
with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different
from any other country on The Back Doctors Podcast with Dr.
Michael Johnson as she describes how The Cox® Technic
System of Spinal Pain Management manages disc
degeneration for relief of chronic low back pain in her patient.
Schedule your West Des Moines chiropractic appointment with
Executive Chiropractic of Iowa today. We can talk about the role
inflammation plays in your back pain experience and how melatonin may address the related disc